Is Epinephrine Bitartrate, Lidocaine Hydrochloride Injection (Xylocaine) in shortage?
Yes. Epinephrine Bitartrate, Lidocaine Hydrochloride Injection is on FDA’s drug shortage list (unavailable), last updated Oct 6, 2026.
Why it’s in shortage
- Demand increase for the drug
- Other
Every listed package
FDA tracks shortages per package. What each maker reports, most recently updated first:
- Xylocaine, Injection, .01 mg/1 mL; 10 mg/1 mL (NDC 63323-482-27)
Check wholesalers for inventory
Maker contact: 888-386-1300
- Xylocaine, Injection, .01 mg/1 mL; 20 mg/1 mL (NDC 63323-483-27)
Check wholesalers for inventory
Maker contact: 888-386-1300
- Xylocaine, Injection, .01 mg/1 mL; 20 mg/1 mL (NDC 63323-483-57)
Check wholesalers for inventory
Maker contact: 888-386-1300
- Xylocaine, Injection, .005 mg/1 mL; 10 mg/1 mL (NDC 63323-487-17)
Check wholesalers for inventory
Maker contact: 888-386-1300
- Xylocaine, Injection, .005 mg/1 mL; 10 mg/1 mL (NDC 63323-487-37)
Check wholesalers for inventory
Maker contact: 888-386-1300
- Xylocaine, Injection, .005 mg/1 mL; 15 mg/1 mL (NDC 63323-488-37)
Check wholesalers for inventory
Maker contact: 888-386-1300
- Xylocaine, Injection, .005 mg/1 mL; 20 mg/1 mL (NDC 63323-489-17)
Check wholesalers for inventory
Maker contact: 888-386-1300
- Lidocaine Hydrochloride And Epinephrine, Injection, 75 mg/5 mL (1.5%; 1:200,000) (NDC 0409-1209-01)
Next Delivery: November 2026; Estimated Recovery: December 2026; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Lidocaine Hydrochloride And Epinephrine, Injection, 250 mg/50 mL (0.5%; 1:200,000) (NDC 0409-3177-01)
Next Delivery and Estimated Recovery: December 2026; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Lidocaine Hydrochloride And Epinephrine, Injection, 200 mg/20 mL (1%; 1:100,000) (NDC 0409-3178-01)
Next Delivery: October 2026; Estimated Recovery: December 2026; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Lidocaine Hydrochloride And Epinephrine, Injection, 300 mg/30 mL (1%; 1:100,000) (NDC 0409-3178-02)
Next Delivery: November 2026; Estimated Recovery: June 2027; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Lidocaine Hydrochloride And Epinephrine, Injection, 500 mg/50 mL (1%; 1:100,000) (NDC 0409-3178-03)
Limited Supply Available. Next Delivery: May 2027; Estimated Recovery: June 2027; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Lidocaine Hydrochloride And Epinephrine, Injection, 450 mg/30 mL (1.5%; 1:200,000) (NDC 0409-3181-01)
Maker contact: 844-646-4398
- Lidocaine Hydrochloride And Epinephrine, Injection, 400 mg/20 mL (2%; 1:100,000) (NDC 0409-3182-01)
Next Delivery and Estimated Recovery: December 2028; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Lidocaine Hydrochloride and Epinephrine, Injection, 600 mg/30 mL (2%; 1:100,000) (NDC 0409-3182-02)
Limited Supply Available. Next Delivery: May 2027; Estimated Recovery: June 2027; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Lidocaine Hydrochloride And Epinephrine, Injection, 1 g/50 mL (2%; 1:100,000) (NDC 0409-3182-03)
Limited Supply Available. Next Delivery: May 2027; Estimated Recovery: June 2027; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Lidocaine Hydrochloride And Epinephrine, Injection, 400 mg/20 mL (2%; 1:200,000) (NDC 0409-3183-01)
Maker contact: 844-646-4398
- Xylocaine, Injection, .005 mg/1 mL; 5 mg/1 mL (NDC 63323-481-57)
Next release September 2026. Check wholesalers for inventory.
Maker contact: 888-386-1300
- Xylocaine, Injection, .01 mg/1 mL; 10 mg/1 mL (NDC 63323-482-17)
Check wholesalers for inventory
Maker contact: 888-386-1300
- Xylocaine, Injection, .01 mg/1 mL; 10 mg/1 mL (NDC 63323-482-57)
Next release September 2026. Check wholesalers for inventory.
Maker contact: 888-386-1300
- Xylocaine, Injection, .005 mg/1 mL; 15 mg/1 mL (NDC 63323-488-17)
Next release September 2026. Check wholesalers for inventory.
Maker contact: 888-386-1300
- Xylocaine, Injection, .005 mg/1 mL; 20 mg/1 mL (NDC 63323-489-27)
Next release September 2026. Check wholesalers for inventory.
Maker contact: 888-386-1300
FDA recalls of the same active ingredient
Recalls can cause or worsen a shortage. These FDA drug recalls share an active ingredient with Epinephrine Bitartrate, Lidocaine Hydrochloride Injection:
- Asclemed USA Inc. recalls Lidocaine HCl Injection USP, 1% (10 mg/mL), 5 mL single dose ampule, Rx Only, Distributed by Enovachem Pharmaceuticals,
- Spectra Medical Devices, Llc recalls Lidocaine HCl Injection USP, 25x5 mL, Single-Dose Ampules, Rx Only, Distributed by: Spectra Medical Devices, LLC,
- Novocol Pharmaceutical of Canada, Inc. recalls Lidocaine HCI 2% and Epinephrine 1:100,000 (Lidocaine HCI and Epinephrine Injection USP), packaged in a carton
- Novocol Pharmaceutical of Canada, Inc. recalls 2% Xylocaine DENTAL with Epinephrine 1:100,000 (Lidocaine HCI and Epinephrine Injection USP), packaged in a carton
- Fresenius Kabi USA, LLC recalls Sensorcaine (Bupivacaine HCl and Epinephrine Injection, USP) with Epinephrine 1:200,000 (as bitartrate), 0.25%, 125 mg
- Fresenius Kabi USA, LLC recalls Sensorcaine-MPF (Bupivacaine HCl and Epinephrine Injection, USP) with Epinephrine 1:200,000 (as bitartrate), 0.25%, 25
- Fresenius Kabi USA, LLC recalls Sensorcaine (Bupivacaine HCl and Epinephrine Injection, USP) with Epinephrine 1:200,000 (as bitartrate), 0.5%, 250 mg
- Mckesson Medical-Surgical Inc. Corporate Office recalls Xylocaine + Epinephrine, multi dose vial 2%, 20 mL, 25 count box, Rx only, MFG: Fresenius Kabi USA LLC, NDC 63323-483-27
- Mckesson Medical-Surgical Inc. Corporate Office recalls Xylocaine + Epinephrine, multi dose vial 1%, packaged in a) 20 mL, 25-count box (NDC 63323-482-27) b) 50 mL, 25-count
- Fresenius Kabi USA LLC recalls Xylocaine-MPF with Epinephrine 1:200,000, (Lidocaine HCl and Epinephrine Injection, USP), 1%, 300 mg/30 mL, (10 mg/mL),
- Fresenius Kabi USA, LLC recalls Sensorcaine-MPF (Bupivacaine HCl and Epinephrine Injection, USP), 0.5%, 150 mg per 30 mL (5 mg per mL), 30 mL Single
- Septodont Inc. recalls Articaine DENTAL, Articane hydrochloride 4% and epinephrine 1:100,000, 50 cartridges. 1.7 mL each, Rx only,
Other forms on FDA’s list
Epinephrine Bitartrate, Lidocaine Hydrochloride Injection shortage questions
Is Epinephrine Bitartrate, Lidocaine Hydrochloride Injection (Xylocaine) in shortage?
Yes. Epinephrine Bitartrate, Lidocaine Hydrochloride Injection is on FDA’s drug shortage list (unavailable), last updated Oct 6, 2026.
Why is there a Epinephrine Bitartrate, Lidocaine Hydrochloride Injection shortage?
FDA records the reason as: Demand increase for the drug; Other.
What should I do if I can’t get Epinephrine Bitartrate, Lidocaine Hydrochloride Injection?
Don’t stop or ration it on your own. Ask your pharmacist whether another strength, package size or maker is in stock, and ask your prescriber about an alternative if none is.
Source: FDA Drug Shortages Database via openFDA. FDA notes that openFDA data is unvalidated and should not be used to make decisions about medical care; ask your pharmacist or prescriber before changing any medication. FDA Drug Shortages Database.