Is Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection (Marcaine With Epinephrine) in shortage?
Yes. Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection is on FDA’s drug shortage list (unavailable), last updated Oct 6, 2026.
Why it’s in shortage
- Delay in shipping of the drug
- Other
Every listed package
FDA tracks shortages per package. What each maker reports, most recently updated first:
- Sensorcaine, Injection, 7.5 mg/1 mL; .005 mg/1 mL (NDC 63323-460-37)
Check wholesaler for inventory
Maker contact: 888-386-1300
- Sensorcaine, Injection, 5 mg/1 mL; .005 mg/1 mL (NDC 63323-462-17)
Check wholesalers for inventory
Maker contact: 888-386-1300
- Sensorcaine, Injection, 5 mg/1 mL; .005 mg/1 mL (NDC 63323-462-31)
Estimated recovery: TBD
Maker contact: 888-386-1300
- Sensorcaine, Injection, 5 mg/1 mL; .005 mg/1 mL (NDC 63323-462-37)
Check wholesalers for inventory
Maker contact: 888-386-1300
- Sensorcaine, Injection, 2.5 mg/1 mL; .005 mg/1 mL (NDC 63323-468-17)
Check wholesalers for inventory
Maker contact: 888-386-1300
- Sensorcaine, Injection, 2.5 mg/1 mL; .005 mg/1 mL (NDC 63323-468-37)
Check wholesaler for inventory
Maker contact: 888-386-1300
- Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 25 mg/10 mL (2.5 mg/mL 1:200,000) (NDC 0409-1746-10)
Maker contact: 844-646-4398
- Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 75 mg/30 mL (2.5 mg/mL 1:200,000) (NDC 0409-1746-30)
Maker contact: 844-646-4398
- Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 50 mg/10 mL (5 mg/mL 1:200,000) (NDC 0409-1749-10)
Maker contact: 844-646-4398
- Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 150 mg/30 mL (5 mg/mL 1:200,000) (NDC 0409-1749-29)
Maker contact: 844-646-4398
- Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 125 mg/50 mL (2.5 mg/mL 1:200,000) (NDC 0409-1752-50)
Maker contact: 844-646-4398
- Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 250 mg/50 mL (5 mg/mL 1:200,000) (NDC 0409-1755-50)
Maker contact: 844-646-4398
- Bupivacaine Hydrochloride And Epinephrine, Injection, 25 mg/10 mL (2.5 mg/mL) (NDC 0409-9042-01)
Next Delivery and Estimated Recovery: December 2028; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Bupivacaine Hydrochloride And Epinephrine, Injection, 75 mg/30 mL (2.5 mg/mL) (NDC 0409-9042-17)
Next Delivery and Estimated Recovery: December 2028; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Bupivacaine Hydrochloride and Epinephrine, Injection, 125 mg/50 mL (2.5 mg/mL) (NDC 0409-9043-01)
Next Delivery and Estimated Recovery: December 2028; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Bupivacaine Hydrochloride And Epinephrine, Injection, 50 mg/10 mL (5 mg/mL) (NDC 0409-9045-01)
Next Delivery and Estimated Recovery: December 2028; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Bupivacaine Hydrochloride and Epinephrine, Injection, 150 mg/30 mL (5 mg/mL) (NDC 0409-9045-17)
Next Delivery and Estimated Recovery: December 2028; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Bupivacaine Hydrochloride And Epinephrine, Injection, 250 mg/50 mL (5 mg/mL) (NDC 0409-9046-01)
Next Delivery and Estimated Recovery: December 2028; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Sensorcaine, Injection, 2.5 mg/1 mL; .005 mg/1 mL (NDC 63323-461-57)
Check wholesaler for inventory
Maker contact: 888-386-1300
- Sensorcaine, Injection, 5 mg/1 mL; .005 mg/1 mL (NDC 63323-463-57)
Check wholesaler for inventory
Maker contact: 888-386-1300
FDA recalls of the same active ingredient
Recalls can cause or worsen a shortage. These FDA drug recalls share an active ingredient with Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection:
- Huons Co., Ltd. recalls Bupivacaine Hydrochloride 0.75% in 8.25% Dextrose Injection, USP (15 mg/2 mL) (7.5 mg/mL) ampules, Rx only,
- Novocol Pharmaceutical of Canada, Inc. recalls Lidocaine HCI 2% and Epinephrine 1:100,000 (Lidocaine HCI and Epinephrine Injection USP), packaged in a carton
- Novocol Pharmaceutical of Canada, Inc. recalls 2% Xylocaine DENTAL with Epinephrine 1:100,000 (Lidocaine HCI and Epinephrine Injection USP), packaged in a carton
- Fresenius Kabi USA, LLC recalls Sensorcaine (Bupivacaine HCl and Epinephrine Injection, USP) with Epinephrine 1:200,000 (as bitartrate), 0.25%, 125 mg
- Fresenius Kabi USA, LLC recalls Sensorcaine-MPF (Bupivacaine HCl and Epinephrine Injection, USP) with Epinephrine 1:200,000 (as bitartrate), 0.25%, 25
- Fresenius Kabi USA, LLC recalls Sensorcaine (Bupivacaine HCl and Epinephrine Injection, USP) with Epinephrine 1:200,000 (as bitartrate), 0.5%, 250 mg
- Mckesson Medical-Surgical Inc. Corporate Office recalls Bupivacaine HCl Injection, single dose vial, Preservative Free 0.5%, 10mL (25/ct), Rx only, Manufacturer: Auromedics
- Mckesson Medical-Surgical Inc. Corporate Office recalls Xylocaine + Epinephrine, multi dose vial 2%, 20 mL, 25 count box, Rx only, MFG: Fresenius Kabi USA LLC, NDC 63323-483-27
- Mckesson Medical-Surgical Inc. Corporate Office recalls Xylocaine + Epinephrine, multi dose vial 1%, packaged in a) 20 mL, 25-count box (NDC 63323-482-27) b) 50 mL, 25-count
- Mckesson Medical-Surgical Inc. Corporate Office recalls Bupivacaine Hydrochloride, USP 0.5% (5mg/mL), 25 vials x 50 mL per box, Rx only, MFG: Pfizer, NDC 0409-1163-01
- Fresenius Kabi USA LLC recalls Xylocaine-MPF with Epinephrine 1:200,000, (Lidocaine HCl and Epinephrine Injection, USP), 1%, 300 mg/30 mL, (10 mg/mL),
- PFIZER, INC recalls 0.5% Bupivacaine Hydrochloride Injection, USP, 150 mg/30 mL (5 mg/mL), 30 mL Single-dose Teartop Vials (NDC
Other forms on FDA’s list
Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection shortage questions
Is Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection (Marcaine With Epinephrine) in shortage?
Yes. Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection is on FDA’s drug shortage list (unavailable), last updated Oct 6, 2026.
Why is there a Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection shortage?
FDA records the reason as: Delay in shipping of the drug; Other.
What should I do if I can’t get Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection?
Don’t stop or ration it on your own. Ask your pharmacist whether another strength, package size or maker is in stock, and ask your prescriber about an alternative if none is.
Source: FDA Drug Shortages Database via openFDA. FDA notes that openFDA data is unvalidated and should not be used to make decisions about medical care; ask your pharmacist or prescriber before changing any medication. FDA Drug Shortages Database.