Is Methylprednisolone Acetate Injection (Depo-Medrol) in shortage?
Yes. Methylprednisolone Acetate Injection is on FDA’s drug shortage list (unavailable), last updated Oct 2, 2026.
Why it’s in shortage
- Demand increase for the drug
- Other
- Shortage of an active ingredient
Every listed package
FDA tracks shortages per package. What each maker reports, most recently updated first:
- Methylprednisolone Acetate, Injection, 80 mg/1 mL (NDC 42023-240-01)
Estimated recovery: TBD
Maker contact: 800-828-9393
- Methylprednisolone Acetate, Injection, 40 mg/1 mL (NDC 55150-313-01)
On backorder. Recovery: TBD. Check wholesalers for inventory
Maker contact: 888-238-7880
- Methylprednisolone Acetate, Injection, 80 mg/1 mL (NDC 55150-314-01)
On backorder. Recovery: TBD. Check wholesalers for inventory
Maker contact: 888-238-7880
- Depo-medrol, Injection, 20 mg/1 mL (NDC 0009-0274-01)
Maker contact: 844-646-4398
- Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-0280-02)
Maker contact: 844-646-4398
- Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-0280-03)
Limited Supply Available. Next Delivery: November 2026; Estimated Recovery: December 2026; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-0280-51)
Maker contact: 844-646-4398
- Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-0280-52)
Maker contact: 844-646-4398
- Depo-medrol, Injection, 80 mg/1 mL (NDC 0009-0306-02)
Maker contact: 844-646-4398
- Depo-medrol, Injection, 80 mg/1 mL (NDC 0009-0306-12)
Maker contact: 844-646-4398
- Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-3073-01)
Limited Supply Available. Next Delivery: October 2026; Estimated Recovery: December 2026
Maker contact: 844-646-4398
- Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-3073-03)
Limited Supply Available. Next Delivery: September 2026; Estimated Recovery: December 2026; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-3073-22)
Next Delivery: October 2026; Estimated Recovery: December 2026
Maker contact: 844-646-4398
- Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-3073-23)
Next Delivery: October 2026; Estimated Recovery: December 2026; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Depo-medrol, Injection, 80 mg/1 mL (NDC 0009-3475-01)
Limited Supply Available. Next Delivery and Estimated Recovery: December 2026
Maker contact: 844-646-4398
- Depo-medrol, Injection, 80 mg/1 mL (NDC 0009-3475-03)
Limited Supply Available. Next Delivery: September 2026; Estimated Recovery: March 2027; Shortage per Manufacturer: Manufacturing Delay
Maker contact: 844-646-4398
- Methylprednisolone Acetate, Injection, 40 mg/1 mL (NDC 25021-820-05)
Estimated recovery: November 2026
Maker contact: 866-625-1618
- Methylprednisolone Acetate, Injection, 40 mg/1 mL (NDC 25021-820-10)
Estimated recovery: November 2026,
Maker contact: 866-625-1618
- Methylprednisolone Acetate, Injection, 80 mg/1 mL (NDC 25021-821-05)
Estimated recovery: November 2026, Product on hand is 8-12 months of dating prior to expiry
Maker contact: 866-625-1618
- Methylprednisolone Acetate, Injection, 40 mg/1 mL (NDC 70121-1573-1)
On backorder. Estimated recovery: late July
Maker contact: 866-525-7270
- Methylprednisolone Acetate, Injection, 40 mg/1 mL (NDC 70121-1573-5)
Maker contact: 866-525-7270
- Methylprednisolone Acetate, Injection, 80 mg/1 mL (NDC 70121-1574-1)
Maker contact: 866-525-7270
- Methylprednisolone Acetate, Injection, 80 mg/1 mL (NDC 70121-1574-5)
Maker contact: 866-525-7270
FDA recalls of Methylprednisolone Acetate
Recalls can cause or worsen a shortage. These FDA drug recalls share an active ingredient with Methylprednisolone Acetate Injection:
- Sagent Pharmaceuticals recalls MethylPREDNISolone Acetate Injectable Suspension, USP, 400 mg per 10 mL (40 mg per mL), 1 x 10 mL Multi-Dose Vial, Rx
- Eugia US LLC recalls Methylprednisolone acetate Injectable Suspension, USP, 400mg per 5mL (80mg/mL, 5mL Multiple-Dose Vial, Rx only, Mfd. in
- Mckesson Medical-Surgical Inc. Corporate Office recalls Depo-Medrol (methylprednisolone acetate injectable suspension, USP) 40 mg/mL, 1 mL single-dose vial, Rx only, MFG:
- Mckesson Medical-Surgical Inc. Corporate Office recalls Depo-Medrol (methylprednisolone acetate injectable suspension, USP) 80mg/mL, packaged in a) 1 mL single-dose vial (NDC#
- Pfizer Inc. recalls Depo-Medrol (methylprednisolone acetate injectable suspension USP), 40 mg/ mL, 1 mL Single-Dose Vial, Rx only,
Methylprednisolone Acetate Injection shortage questions
Is Methylprednisolone Acetate Injection (Depo-Medrol) in shortage?
Yes. Methylprednisolone Acetate Injection is on FDA’s drug shortage list (unavailable), last updated Oct 2, 2026.
Why is there a Methylprednisolone Acetate Injection shortage?
FDA records the reason as: Demand increase for the drug; Other; Shortage of an active ingredient.
What should I do if I can’t get Methylprednisolone Acetate Injection?
Don’t stop or ration it on your own. Ask your pharmacist whether another strength, package size or maker is in stock, and ask your prescriber about an alternative if none is.
Source: FDA Drug Shortages Database via openFDA. FDA notes that openFDA data is unvalidated and should not be used to make decisions about medical care; ask your pharmacist or prescriber before changing any medication. FDA Drug Shortages Database.