Is Methotrexate Sodium Injection in shortage?
Yes. Methotrexate Sodium Injection is on FDA’s drug shortage list (unavailable), last updated Oct 6, 2026.
Why it’s in shortage
- Demand increase for the drug
- Other
Every listed package
FDA tracks shortages per package. What each maker reports, most recently updated first:
- Methotrexate Preservative Free, Injection, 1 g (NDC 63323-122-50)
Check wholesaler for inventory
Maker contact: 888-386-1300
- Methotrexate Sodium, Injection, 25 mg/1 mL (NDC 63323-123-10)
Check wholesaler for inventory
Maker contact: 888-386-1300
- Methotrexate Sodium Preservative Free, Injection, 25 mg/1 mL (NDC 16729-277-30)
Estimated recovery: October Week 1 2026; Short dated inventory with expiry of 09/30/27 available
Maker contact: 866-941-7875, option 2
- Methotrexate Sodium Preservative Free, Injection, 25 mg/1 mL (NDC 16729-277-35)
Short dated inventory with expiry of 8/31/2027 available; Estimated recovery: Jan 2027
Maker contact: 866-941-7875, option 2
- Methotrexate Sodium Preservative Free, Injection, 25 mg/1 mL (NDC 0703-3671-01)
Estimated recovery: October 2026
Maker contact: 800-545-8800
- Methotrexate Sodium Preservative Free, Injection, 25 mg/1 mL (NDC 0703-3675-01)
Estimated Recovery: Novemeber 2026
Maker contact: 800-545-8800
- Methotrexate Sodium Preservative Free, Injection, 25 mg/1 mL (NDC 0703-3678-01)
Estimated recovery: October 2026
Maker contact: 800-545-8800
- Methotrexate Sodium, Injection, 1 g/40 mL (25 mg/mL) (NDC 61703-124-40)
Maker contact: 844-646-4398
- Methotrexate Sodium, Injection, 50 mg/2 mL (25 mg/mL) (NDC 61703-350-10)
Maker contact: 844-646-4398
- Methotrexate Sodium, Injection, 50 mg/2 mL (25 mg/mL) (NDC 61703-350-38)
Maker contact: 844-646-4398
- Methotrexate Sodium, Injection, 1 g/40 mL (25 mg/mL) (NDC 61703-408-25)
Maker contact: 844-646-4398
- Methotrexate Sodium, Injection, 1 g/40 mL (25 mg/mL) (NDC 61703-408-41)
Maker contact: 844-646-4398
- Methotrexate, Preservative Free, Injection, 25 mg/1 mL (NDC 0143-9519-10)
Additional lots will be available in the October 2026 timeframe. Product will be made available as it is released.
Maker contact: 800-631-2174
- Methotrexate, Preservative Free, Injection, 1 g (NDC 0143-9830-01)
Additional lots will be available in the September 2026 timeframe. Product will be made available as it is released.
Maker contact: 800-631-2174
FDA recalls of the same active ingredient
Recalls can cause or worsen a shortage. These FDA drug recalls share an active ingredient with Methotrexate Sodium Injection:
- West-Ward Columbus Inc recalls Methotrexate Tablets, USP, 2.5 mg, 10x10 Unit-Dose Tablets per carton, Rx only, Distributed by: West-Ward
- Cardinal Health Inc. recalls Methotrexate Injection, USP 50 mg/2mL (25 mg/mL) 5 x 2mL Single-Dose Vials, Sterile, Rx Only, Distributed by Hospira,
- Hospira Inc. recalls Methotrexate Injection, USP, 25 mg/mL, 40 mL Single Dose Vial, Rx only, antineoplastic/cytotoxic agent; Manufactured
Methotrexate Sodium Injection shortage questions
Is Methotrexate Sodium Injection in shortage?
Yes. Methotrexate Sodium Injection is on FDA’s drug shortage list (unavailable), last updated Oct 6, 2026.
Why is there a Methotrexate Sodium Injection shortage?
FDA records the reason as: Demand increase for the drug; Other.
What should I do if I can’t get Methotrexate Sodium Injection?
Don’t stop or ration it on your own. Ask your pharmacist whether another strength, package size or maker is in stock, and ask your prescriber about an alternative if none is.
Source: FDA Drug Shortages Database via openFDA. FDA notes that openFDA data is unvalidated and should not be used to make decisions about medical care; ask your pharmacist or prescriber before changing any medication. FDA Drug Shortages Database.